Impressive Bleeding Profile With Factor XI Inhibitor in AF

Impressive Bleeding Profile With Factor XI Inhibitor in AF

xFurther details from the phase 2b AZALEA trial with the factor XI inhibitor abelacimab (Anthos) show significant reductions in major and clinically relevant nonmajor bleeding compared with rivaroxaban for patients with AF; the risk of stroke was moderate to high. The trial was stopped earlier this year because of an “overwhelming” reduction in bleeding with …

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ORBITA-2 Saves Interventional Cardiology, Questions Guidance

ORBITA-2 Saves Interventional Cardiology, Questions Guidance

When Christopher Rajkumar, MD, presented the positive results of ORBITA-2, the second placebo-controlled trial of percutaneous coronary intervention (PCI) in stable angina, you could almost feel the relief of cardiologists at the American Heart Association meeting. All is right again. Thank goodness. The first ORBITA trial stunned our community when it showed that PCI compared …

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