A study published in The EMBO Journal opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumor necrosis factor-α (TNF-α) and its receptors TNFR, molecules of key interest in biomedicine due to their involvement in multiple diseases such as obesity-related to type 2 diabetes mellitus, …
The year was 1948. It had only been about half a century since scientists had rediscovered Gregor Mendel’s work on inheritance in pea plants. This year, a scientist working on the genetics of the maize plant would challenge the then prevailing concept that genes are stable and arranged in an orderly manner on the chromosome. …
Statement of principal findings In England, although the PAF of modifiable risk factors for dementia showed a downward trend across 2004–2019, this temporal trend was slight and insignificant, with a substantial proportion of dementia cases (38%) still attributable, assuming causal relationships, to MRFs in 2018/2019. Hypertension has been the primary MRF driving the dementia burden, …
In this insightful interview from SLAS 2024, we talk with Dr. Abidemi Junaid, a scientist at the Hansjörg Wyss Institute for Biologically Inspired Engineering at Harvard University. Junaid spearheads the development of the human Vagina Chip, a pioneering tool designed to study host-microbiome interactions in bacterial vaginosis and pave the way for biotherapeutic development and validation. …
This is an observational, case–control study reported in accordance with the STROBE guidelines (see Additional file 1: Checklist S1). Study sample The UK Biobank is a UK-wide prospective cohort study, with baseline recruitment taking place between March 2006 and October 2010. At the time of this study, there were 227,297 participants who had completed consent …
Study population The UKB is a prospective cohort study of around 500,000 individuals aged 40–69 years enrolled between 2006 and 2010 across 22 centers located in England, Scotland, and Wales. At recruitment, information on socio-demographic characteristics, lifestyle factors, diet, anthropometry, and biological samples were collected [23]. Participants were followed from recruitment until the earliest of cancer, …
Powell EE, Wong VW, Rinella M. Non-alcoholic fatty liver disease. Lancet. 2021;397(10290):2212–24. CAS PubMed Google Scholar Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and …