A study published in The EMBO Journal opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumor necrosis factor-α (TNF-α) and its receptors TNFR, molecules of key interest in biomedicine due to their involvement in multiple diseases such as obesity-related to type 2 diabetes mellitus, …
In a recent study published in JAMA Surgery, researchers investigated whether Roux-en-Y gastric bypass (RYGB) reduces cardiovascular risk factors independent of calorie restriction and weight loss. Study: Gastric Bypass vs Diet and Cardiovascular Risk Factors A Nonrandomized Controlled Trial. Image Credit: Adao/Shutterstock.com Background Bariatric surgery is more effective than nonsurgical treatment for reducing body weight …
Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. The results, published on May 29 in Developmental Cell, overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has …
In a recent study published in Ecotoxicology and Environmental Safety, researchers aimed to investigate the effects of polystyrene microplastics on pregnancy outcomes and glucose metabolism. Study: Polystyrene microplastics disturb maternal glucose homeostasis and induce adverse pregnancy outcomes. Image Credit: Sansoen Saengsakaorat/Shutterstock.com Background For this, they developed a murine model system (C57BL/6J mice) and administered varying dosages of …
In a recent study published in the International Journal of Impotence Research, researchers analyze nationwide inpatient data provided by the Federal Bureau of Statistics of Germany to evaluate the in-hospital outcomes and overall trends in cases of high- and low-flow priapism. These data were used to better understand potential treatment and management measures for both conditions. …
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen responsible for the coronavirus disease 2019 (COVID-19), has been associated with the manifestation of adverse pulmonary conditions, such as pneumonia and acute respiratory distress syndrome (ARDS). A recent Nature Communications study identifies ferroptosis as a major cell death mechanism underlying COVID-19 lung disease. Study: Fatal COVID-19 pulmonary disease involves ferroptosis. Image Credit: Mang E / …
In a new paper, researchers from clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine (“Insilico”), in collaboration with NVIDIA, present a new large language model (LLM) transformer for solving biological and chemical tasks called nach0. The multi-domain and multi-task LLM was trained on a diverse set of tasks, natural language understanding, synthetic route …
A recent Cancer Research study assessed the effect of tobacco smoking and electronic cigarette (e-cigarettes) use on DNA methylation changes associated with carcinogenesis. Study: Cigarette smoking and e-cigarette use induce shared DNA methylation changes linked to carcinogenesis. Image Credit: Andrey_Popov/Shutterstock.com Background In comparison to tobacco smoking, the use of e-cigarettes and smokeless, non-combustible tobacco has often been …
A gene associated with colorectal cancer appears to also play a role in the development of other solid tumors, according to a study of over 350,000 patient biopsy samples conducted by researchers at the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health and Foundation Medicine. Since the early 2000s, scientists have known that …
Aging may be less about specific “aging genes” and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece publishing March 21 in the journal Trends in Genetics. A decline in the expression of long genes …