The new uLIPSTIC technology can track the physical interactions between cells, such as the above depiction of a dendritic cell activating a T cell. | Photo Credit: Rockefeller University A fundamental goal of basic biology is understanding how diverse cell types work in concert to form tissues, organs, and organ systems. While recent efforts to …
A fundamental goal of basic biology is understanding how diverse cell types work in concert to form tissues, organs, and organ systems. While recent efforts to catalogue the different cell types in every tissue in human bodies are a step in the right direction, they address only one piece of the puzzle. The big mystery …
A recent Science Immunology study revealed that neonatal gut bacteria produce serotonin and down-regulate monoamine oxidase A (MOA) to limit serotonin breakdown, thereby promoting immune tolerance. Study: Gut bacteria–derived serotonin promotes immune tolerance in early life. Image Credit: Tatiana Shepeleva/Shutterstock.com Background Bacterial colonization in the neonatal gut plays a crucial role in the development of the immune …
In this insightful interview from SLAS 2024, we talk with Dr. Abidemi Junaid, a scientist at the Hansjörg Wyss Institute for Biologically Inspired Engineering at Harvard University. Junaid spearheads the development of the human Vagina Chip, a pioneering tool designed to study host-microbiome interactions in bacterial vaginosis and pave the way for biotherapeutic development and validation. …
New research from Oregon Health & Science University describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos. Researchers at OHSU documented in vitro gametogenesis, or IVG, in a mouse model through the preliminary steps of a technique that relies …
In a recent review published in the journal Nature Reviews Microbiology, a group of authors summarized recent advancements in understanding long coronavirus disease (COVID) ‘s mechanisms, impacts, and research needs for better diagnostics and treatments. Review: Long COVID: major findings, mechanisms and recommendations Background Long COVID, affecting over 65 million globally, manifests through diverse, systemic symptoms …
Across the globe, more than 39 million people are living with the Human Immunodeficiency Virus (HIV), the virus that causes AIDS, including more than 1.3 million new HIV diagnoses last year. The majority of those afflicted -; approximately 76% -; have access to antiviral therapy that allows them to live with HIV as a chronic …
A study published in the journal Nature Communications provides a comprehensive evaluation of the genetics of circulating retinol and its influence on human health. Study: Genetic influences on circulating retinol and its relationship to human health Background Vitamin A is a fat-soluble micronutrient involved in various physiological processes, including vision, cell division, immune function, and neurodevelopment. …
Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol. The team, led by Stanley Hazen, M.D., Ph.D., discovered a link between 4PY, a breakdown product from excess niacin, and heart disease. Higher circulating levels of 4PY …
Researchers led by Northwestern University and the University of Wisconsin-Madison have introduced a pioneering approach aimed at combating neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis (ALS). In a new study, researchers discovered a new way to enhance the body’s antioxidant response, which is crucial for cellular protection against the oxidative stress …