A recent Cell Discovery study investigates whether the ketogenic diet (KD) could alleviate epilepsy. Study: Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy. Image Credit: SewCreamStudio / Shutterstock.com Background The ketogenic diet (KD) is a high-fat, very low carbohydrate, and adequate protein regimen. In this diet, cell energy is derived …
In a recent study published in Physiological Genomics, a group of researchers explored how sex hormones and chromosomes influence allergic inflammation and gene expression in four-core genotype (FCG) mice exposed to house dust mites (HDMs). Study: Transcriptomics analysis of allergen-induced inflammatory gene expression in the Four-Core Genotype mouse model. Image Credit: SciePro/Shutterstock.com Background Asthma, affecting …
In a recent study published in Nature Medicine, a group of researchers evaluated the impact of vegan and ketogenic diets on immune response and gut microbiota in humans. Study: Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans. Image Credit: Boontoom Sae-Kor/Shutterstock.com Background Nutrition significantly influences physiological processes, including immune regulation, offering …
A recent Lancet Microbe study explores intrahost evolution and the risk factors associated with prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised patients. Study: SARS-CoV-2 shedding and evolution in immunocompromised patients during the omicron period: a multicentre, prospective analysis. Image Credit: Sabrewolf / Shutterstock.com Background Immunocompromised patients are most vulnerable to SARS-CoV-2 infection, as they …
In a recent study published in the journal Nature, researchers developed and tested a novel dry powder aerosol vaccine against COVID-19. The nanoparticle-based vaccine comprises cholera toxin B subunits with the SARS-CoV-2 RBD antigens. Study findings revealed that this single-use nasal spray promotes the robust production of IgG and IgA antibodies and bolsters local T …
In a recent study published in Cancer Cell, researchers performed a molecular analysis of neuroendocrine neoplasm (NEN) patient-derived tumor organoids (PDTOs) and their parental neoplasms. Study: Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites. Image Credit: Aunt Spray/Shutterstock.com Background Neuroendocrine neoplasms (NECs) are malignancies most commonly …
Human fingers and toes do not grow outward; instead, they form from within a larger foundational bud, as intervening cells recede to reveal the digits beneath. This is among many processes captured for the first time as scientists unveil a spatial cell atlas of the entire developing human limb, resolved in space and time. Image …
The lab of Yongchao C. Ma, PhD, at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago uncovered a novel mechanism that leads to motor neuron degeneration in spinal muscular atrophy (SMA). This discovery offers a new target for treatment that overcomes important limitations of gene therapy and other …
In a review published in the journal Advanced Science, researchers discussed the interplay of the immune system and the sympathetic regulation of vital metabolic organs such as the pancreas, intestine, liver, and adipose tissues. Insights from the review help improve our understanding of metabolic regulation of organs and pave the way for new therapeutic strategies …
In a recent study published in The Journal of Antibiotics, a group of researchers analyzed the trends in antimicrobial resistance among urogenital Mycoplasma hominis (M. hominis) and Ureaplasma species in Greece, utilizing 2,992 Ureaplasma spp. and 371 M. hominis isolates from 2014 to 2022, assessing their sensitivity to various antibiotics. Study: Antimicrobial resistance rates of urogenital Mycoplasma …