An eye-opening new study from genetic scientists at the University of Colorado-Boulder has discovered something surprising and alarming about some mysterious foreign DNA found in the human genome. This DNA was introduced into the genomes of human ancestors tens of millions of years ago by ancient retroviruses, and has survived intact even into the modern …
In a recent study published in the journal Nucleic Acids Research, researchers investigate whether machine learning can identify pan-cancer mutational hotspots at persistent CCCTC-binding factor (P-CTCF) binding sites (P-CTCFBSs). Study: Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites. Image Credit: Nuttapong punna / Shutterstock.com CTCF and cancer CTCF-binding site mutations impact …
Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. The results, published on May 29 in Developmental Cell, overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has …
In a new paper, researchers from clinical stage artificial intelligence (AI)-driven drug discovery company Insilico Medicine (“Insilico”), in collaboration with NVIDIA, present a new large language model (LLM) transformer for solving biological and chemical tasks called nach0. The multi-domain and multi-task LLM was trained on a diverse set of tasks, natural language understanding, synthetic route …
A recent Cancer Research study assessed the effect of tobacco smoking and electronic cigarette (e-cigarettes) use on DNA methylation changes associated with carcinogenesis. Study: Cigarette smoking and e-cigarette use induce shared DNA methylation changes linked to carcinogenesis. Image Credit: Andrey_Popov/Shutterstock.com Background In comparison to tobacco smoking, the use of e-cigarettes and smokeless, non-combustible tobacco has often been …
Aging may be less about specific “aging genes” and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece publishing March 21 in the journal Trends in Genetics. A decline in the expression of long genes …
A recent study published in Nature Medicine demonstrated genetic heterogeneity of blood pressure (BP) effects between sexes. Study: Sex-specific genetic architecture of blood pressure. Image Credit: Chompoo Suriyo/Shutterstock.com Background Environmental exposures and interactions influence BP traits with a complex and well-defined genetic architecture, with about 30% to 50% heritability. Hypertension is highly heritable and a significant risk …
A team of researchers have zeroed down on a genetic change that may be responsible for the loss of tails in humans. When the genes were inserted into mice, some of them lost their tails too. The researchers intend to investigate the genes further, and examine any trade-offs of tail loss. New research sheds …
ANI | Updated: Feb 23, 2024 22:06 IST Washington DC [US], February 23 (ANI): Certain hypertension-related genes influence blood pressure from an early age and raise the risk of cardiovascular disease as you become older. However, there is something you can do about it.“We are talking about really small differences, so small that they may …
A study published in the journal Nature Communications provides a comprehensive evaluation of the genetics of circulating retinol and its influence on human health. Study: Genetic influences on circulating retinol and its relationship to human health Background Vitamin A is a fat-soluble micronutrient involved in various physiological processes, including vision, cell division, immune function, and neurodevelopment. …