in vitro - Samachar Central

Machine learning identifies cancer-driving mutations at CTCF binding sites

2024-07-08 08:29 AM

In a recent study published in the journal Nucleic Acids Research, researchers investigate whether machine learning can identify pan-cancer mutational hotspots at persistent CCCTC-binding factor (P-CTCF) binding sites (P-CTCFBSs). Study: Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites. Image Credit: Nuttapong punna / Shutterstock.com CTCF and cancer CTCF-binding site mutations impact …

Unique bacteria colonize the gut shortly after birth and make serotonin to educate gut immune cells

2024-03-21 04:54 AM

A recent Science Immunology study revealed that neonatal gut bacteria produce serotonin and down-regulate monoamine oxidase A (MOA) to limit serotonin breakdown, thereby promoting immune tolerance. Study: Gut bacteria–derived serotonin promotes immune tolerance in early life. Image Credit: Tatiana Shepeleva/Shutterstock.com Background Bacterial colonization in the neonatal gut plays a crucial role in the development of the immune …

Nanoparticles turbocharge turmeric’s curcumin for enhanced health benefits

2024-03-18 07:18 AM

A review article published in the journal Antioxidants provides a detailed overview of nanoparticle-based strategies to improve the bioavailability and bioactivity of curcumin. Study: Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment. Image Credit: Microgen / Shutterstock Background Curcumin, turmeric’s main bioactive compound, is a polyphenol found in Curcuma longa roots. This compound has …

Scientists transform skin cells into functional eggs in mice

2024-03-09 02:24 PM

New research from Oregon Health & Science University describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos. Researchers at OHSU documented in vitro gametogenesis, or IVG, in a mouse model through the preliminary steps of a technique that relies …

Targeted ocular spectroscopy shines new light on retinal health

2024-01-02 09:06 AM

In a recent study published in the Journal of Biomedical Optics, researchers demonstrate the multimodal functionality of targeted ocular fluorescence spectroscopy in vitro and in vivo. Study: Targeted spectroscopy in the eye fundus. Image Credit: PeopleImages.com – Yuri A / Shutterstock.com Background Some typical structural and functional changes occur in the eyes, especially the eye fundus, due to ocular diseases like …

Immunogenicity of insect-specific Zika virus-vectorized vaccine candidates

2023-11-17 05:29 PM

In a recent study published in Scientific Reports, researchers investigated the immunogenicity, safety, and effectiveness of Aripo-Zika (ARPV/ZIKV), a chimeric insect-specific flavivirus (ISFV)-Zika vaccine. Study: Exploring the immunogenicity of an insect-specific virus vectored Zika vaccine candidate. Image Credit: nechaevkon/Shutterstock.com Background The Zika virus (ZIKV) is a worldwide health issue; however, there are no Food and Drug Administration …