Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccines

Influenza vaccines and vaccine viruses used during the 2018−2019 and 2019−2020 study seasons This study was a randomized, open-label trial conducted in the United States during the Northern Hemisphere 2018−2019 (Year 1, n = 723) and 2019−2020 (Year 2, n = 684) influenza seasons (Fig. 1). In year 1, HCP were randomized to receive one of four influenza vaccines: ccIIV4 …

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