Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. The results, published on May 29 in Developmental Cell, overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has …
A gene associated with colorectal cancer appears to also play a role in the development of other solid tumors, according to a study of over 350,000 patient biopsy samples conducted by researchers at the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health and Foundation Medicine. Since the early 2000s, scientists have known that …
By Jason Gale A breakthrough therapy that can cure blood cancer generated a dramatic response in brain cancer, rekindling optimism that the technique using a patient’s own immune system might help fight solid tumors. Tumors rapidly shrank within days in the first three glioblastoma patients who received the novel immunotherapy at Massachusetts General Hospital last …
Hello. I’m David Kerr, professor of cancer medicine, from University of Oxford. I’d like to talk today about a nice editorial in Lancet Oncology written by Grimes and O’Riordan from Trinity in Dublin, entitled, “Quackery: Starving Cancer and Other Dangerous Dietary Misconceptions.” I’ll address what these misconceptions are, but perhaps also think about whether there …
In a recent study published in the journal JAMA Network Open, researchers evaluated the incidence of breast cancer among young women between the ages of 20 and 49 years. They assessed the incidence according to age at diagnosis, tumor stage, estrogen and progesterone hormone receptor status, and race and ethnicity. Study: Breast Cancer Incidence Among …
Neuroblastoma mainly affects toddlers and young children – in the EU region there are 1500 new cases per year. Neuroblastoma is a malignant tumor of the peripheral nervous system and around 50% of patients are high-risk cases. Recurrences occur frequently, and conventional therapies are no longer effective for these children. With liquid biopsies it is …
Bladder cancer is currently treated in its earlier stages by localized intravesical chemotherapy or immunotherapy after removing the tumor. However, recurrences occur in up to 70% of patients at 5 years, while up to 30% fail to respond. This means a constant need to monitor and retreat these patients, driving costs sky-high for the treatment …
In a recent study published in Cancer Cell, researchers performed a molecular analysis of neuroendocrine neoplasm (NEN) patient-derived tumor organoids (PDTOs) and their parental neoplasms. Study: Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites. Image Credit: Aunt Spray/Shutterstock.com Background Neuroendocrine neoplasms (NECs) are malignancies most commonly …
In a recent review published in the journal Nutrients, researchers investigated available literature on the impacts of obesity and overweight on prostate cancer. Additionally, they discuss whether a father’s offspring can inherit the condition. Their review of over 280 publications reveals that obesity does indeed contribute to carcinogenesis risk, and obesity-associated epigenetic modifications can promote …
Treating cancer is becoming increasingly complex, but also offers more and more possibilities. After all, the better a tumor’s biology and genetic features are understood, the more treatment approaches there are. To be able to offer patients personalized therapies tailored to their disease, laborious and time-consuming analysis and interpretation of various data is required. Researchers …